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Regenerative duo · 再生修复研究

TB-500 + BPC-157

结缔组织与血管修复的双肽工具

技术数据LZH-007
代号
Regenerative duo
半衰期
TB-500: hours; BPC-157: short plasma, longer tissue residence
研究给药途径
Subcutaneous / IM (research)
分子靶点
G-actin (TB-500) · VEGFR2 / NO-pathway / GH-R upregulation (BPC-157)
发现 / 披露
TB-500: synthetic Tβ4 active fragment, 1990s; BPC-157: Sikiric lab, Zagreb, 1991
目标纯度
≥ 98%
建议储存
−20°C 避光,复溶后 2~8°C
别名
Thymosin β4 fragment (1-4 + 17-23) + Body Protection Compound 157
外观
White lyophilized powder
溶解性
Both highly water soluble
氨基酸序列
TB-500: Ac-LKKTETQ | BPC-157: GEPPPGKPADDAGLV
分析人员审阅当前批次的HPLC色谱图
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

技术人员在放大生产过程中监测不锈钢反应釜
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

概述

TB-500为胸腺素β4活性片段;BPC-157为源自胃保护蛋白的稳定五肽。两者常作为组织修复研究的工具组合。

02

药理与机制

TB-500结合G-actin,促进细胞迁移与新生血管形成;BPC-157调节VEGFR2、一氧化氮通路与肌腱成纤维细胞活性。

03

研究方向

R.01
结缔组织与血管修复的双肽工具

用于肌腱韧带损伤、消化道屏障、缺血再灌注及神经修复的临床前模型。

04

结构信息

TB-500:17氨基酸片段(Ac-SDKP扩展序列)。BPC-157:GEPPPGKPADDAGLV十五肽稳定化序列。

氨基酸序列
TB-500: Ac-LKKTETQ | BPC-157: GEPPPGKPADDAGLV
仅供科研用途。不构成医疗建议,不用于诊断或治疗。