长效胰高血糖素样肽-1受体激动剂
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.
司美格鲁肽是一种长效GLP-1受体激动剂，通过31个氨基酸组成的修饰多肽序列实现每周一次的给药频率。其结构基于天然GLP-1，并在第26位赖氨酸引入脂肪酸侧链以延长半衰期。
激活GLP-1受体后，促进葡萄糖依赖性胰岛素分泌、抑制胰高血糖素释放、延缓胃排空，并作用于下丘脑食欲中枢。其作用具有葡萄糖依赖性，因此低血糖风险较低。
广泛用于2型糖尿病代谢控制、肥胖治疗及心血管风险研究。当前研究方向包括神经退行性疾病、非酒精性脂肪肝及成瘾行为调节。
31氨基酸修饰多肽，含C18双酸侧链与γGlu-2xOEG连接子，赋予长效白蛋白结合特性。
