01
概述
Semax为合成七肽，源自ACTH(4-7)序列，C端Pro-Gly-Pro延伸提高稳定性。
02
药理与机制
上调BDNF与神经营养因子表达，调节脑内单胺递质并影响神经可塑性。
03
研究方向
R.01
ACTH(4-7)稳定化类似物
缺血性脑损伤、注意力与学习记忆研究中的经典工具肽。
04
结构信息
七肽Met-Glu-His-Phe-Pro-Gly-Pro。
氨基酸序列
Met-Glu-His-Phe-Pro-Gly-Pro
仅供科研用途。不构成医疗建议，不用于诊断或治疗。
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lyophilized
ACTH(4-7) analog · 神经认知研究
Semax
ACTH(4-7)稳定化类似物
技术数据LZH-015
- 代号
- ACTH(4-7) analog
- 半衰期
- Short plasma; central activity hours
- 研究给药途径
- Intranasal (research)
- 分子靶点
- BDNF / NGF upregulation · monoamine modulation
- 发现 / 披露
- Institute of Molecular Genetics, Moscow, 1980s
- 目标纯度
- ≥ 98%
- 建议储存
- −20°C 避光，复溶后 2~8°C
别名
ACTH(4-7) PGP analog
外观
White lyophilized powder
溶解性
Water soluble
氨基酸序列
Met-Glu-His-Phe-Pro-Gly-Pro
FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.
FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.