01
概述
Selank为天然Tuftsin的合成类似物，七肽序列，C端经稳定化修饰。
02
药理与机制
调节GABA能、单胺与神经营养因子表达，对应激与认知相关脑区有调节作用。
03
研究方向
R.01
稳定化Tuftsin类似物
焦虑模型、认知表现与免疫神经调节研究中的工具肽。
04
结构信息
七肽Thr-Lys-Pro-Arg-Pro-Gly-Pro，C端Pro延伸序列。
氨基酸序列
Thr-Lys-Pro-Arg-Pro-Gly-Pro
仅供科研用途。不构成医疗建议，不用于诊断或治疗。
← 返回列表条目 · LZH-014
lyophilized
TP-7 analog · 焦虑与认知研究
Selank
稳定化Tuftsin类似物
技术数据LZH-014
- 代号
- TP-7 analog
- 半衰期
- Short plasma (~minutes); central effects persist hours
- 研究给药途径
- Intranasal (research)
- 分子靶点
- GABAergic, monoaminergic and BDNF expression modulation
- 发现 / 披露
- Russian Academy of Sciences / Institute of Molecular Genetics, 1990s
- 目标纯度
- ≥ 98%
- 建议储存
- −20°C 避光，复溶后 2~8°C
别名
TP-7 stabilized analog
外观
White lyophilized powder
溶解性
Water soluble
氨基酸序列
Thr-Lys-Pro-Arg-Pro-Gly-Pro
FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.
FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.