01
概述
KPV为α-黑色素细胞刺激激素（α-MSH）C末端的三肽片段（Lys-Pro-Val），保留了关键的抗炎活性。
02
药理与机制
下调NF-κB信号、抑制促炎细胞因子表达；在肠道与黏膜模型中表现出屏障保护作用。
03
研究方向
R.01
α-MSH的C端三肽片段
炎症性肠病、皮肤炎症与黏膜屏障研究中的工具分子。
04
结构信息
三肽序列Lys-Pro-Val，小分子量便于多种递送方式。
氨基酸序列
Lys-Pro-Val
仅供科研用途。不构成医疗建议，不用于诊断或治疗。
← 返回列表条目 · LZH-009
lyophilized
α-MSH fragment · 免疫调节短肽
KPV
α-MSH的C端三肽片段
技术数据LZH-009
- 代号
- α-MSH fragment
- 分子式
- C19H28N6O4
- 分子量
- 404.5 Da
- 半衰期
- Short plasma half-life; mucosal residence reported
- 研究给药途径
- Oral / topical / SC (research)
- 分子靶点
- NF-κB downregulation · MC1R-independent anti-inflammatory pathway
- 发现 / 披露
- Identified as C-terminal active fragment of α-MSH, 1980s
- 目标纯度
- ≥ 98%
- 建议储存
- −20°C 避光，复溶后 2~8°C
别名
α-MSH(11-13), Lysine-Proline-Valine tripeptide
外观
White lyophilized powder
溶解性
Freely water soluble
氨基酸序列
Lys-Pro-Val
FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.
FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.