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Delta sleep peptide · 睡眠与神经内分泌

DSIP

δ-睡眠诱导肽

技术数据LZH-013
代号
Delta sleep peptide
分子式
C35H48N10O15
分子量
848.8 Da
半衰期
~7-15 min (plasma)
研究给药途径
Subcutaneous / IV (research)
分子靶点
Neuroendocrine modulation; precise receptor not fully resolved
发现 / 披露
Schoenenberger & Monnier, Bern, 1977
目标纯度
≥ 98%
建议储存
−20°C 避光,复溶后 2~8°C
别名
Delta sleep-inducing peptide
外观
White lyophilized powder
溶解性
Water soluble
氨基酸序列
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
分析人员审阅当前批次的HPLC色谱图
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

技术人员在放大生产过程中监测不锈钢反应釜
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

概述

DSIP(Delta Sleep Inducing Peptide)为九肽,最早从兔脑灌注液中分离,具有调节慢波睡眠的活性。

02

药理与机制

调节神经递质释放与皮质醇昼夜节律,对应激轴具有缓冲作用。

03

研究方向

R.01
δ-睡眠诱导肽

睡眠生理、应激响应与神经内分泌节律研究中的经典工具肽。

04

结构信息

九肽Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu。

氨基酸序列
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
仅供科研用途。不构成医疗建议,不用于诊断或治疗。