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MOTS-c + 5-Amino-1MQ + NAD+ · 代谢与长寿复合

Biomtide

线粒体衍生肽与NAD+前体的复合研究方案

技术数据LZH-010
代号
MOTS-c + 5-Amino-1MQ + NAD+
半衰期
MOTS-c: ~hours; NAD+: rapid turnover; 5-Amino-1MQ: oral t½ ~hours
研究给药途径
Subcutaneous (peptide); oral (small molecules) (research)
分子靶点
AMPK axis (MOTS-c) · NNMT inhibition (5-Amino-1MQ) · sirtuins / PARPs (NAD+)
发现 / 披露
MOTS-c identified by Lee & Cohen, USC, 2015
目标纯度
≥ 98%
建议储存
−20°C 避光,复溶后 2~8°C
别名
MOTS-c + 5-Amino-1MQ + NAD+
外观
White to slightly cream lyophilized powder
溶解性
MOTS-c and NAD+ water soluble; 5-Amino-1MQ DMSO/water
氨基酸序列
MOTS-c: MRWQEMGYIFYPRKLR (16 aa, mtDNA 12S-rRNA derived)
分析人员审阅当前批次的HPLC色谱图
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

技术人员在放大生产过程中监测不锈钢反应釜
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

概述

Biomtide是MOTS-c线粒体衍生肽、NNMT抑制剂5-Amino-1MQ与NAD+的复合研究制剂,用于探索代谢与衰老干预的协同效应。

02

药理与机制

MOTS-c调节AMPK通路与胰岛素敏感性;5-Amino-1MQ抑制NNMT,保留SAM甲基库;NAD+作为辅酶支持sirtuin与线粒体功能。

03

研究方向

R.01
线粒体衍生肽与NAD+前体的复合研究方案

用于代谢综合征、肌肉功能、线粒体生物发生与衰老干预的复合研究模型。

04

结构信息

MOTS-c:16氨基酸线粒体衍生肽;5-Amino-1MQ:小分子甲基喹啉;NAD+:天然辅酶。

氨基酸序列
MOTS-c: MRWQEMGYIFYPRKLR (16 aa, mtDNA 12S-rRNA derived)
仅供科研用途。不构成医疗建议,不用于诊断或治疗。