SS-31

Cardiolipin-binding mitochondrial peptide

Ficha técnicaLZH-004

Código: Elamipretide
Fórmula: C32H49N9O5
Masa molecular: 639.8 Da
Semivida: ~2 h (plasma); mitochondrial residence much longer
Vía de investigación: Subcutaneous / IV (research)
Dianas moleculares: Cardiolipin (inner mitochondrial membrane)
Descubrimiento / divulgación: Szeto-Schiller laboratory, Cornell, ca. 2004
Pureza objetivo: ≥ 98%
Almacenamiento recomendado: −20 °C, protegido de la luz. De 2 a 8 °C tras la reconstitución.

Sinónimos

Elamipretide, MTP-131, Bendavia

Aspecto

White lyophilized powder

Solubilidad

Freely soluble in water

Secuencia

D-Arg-Dmt-Lys-Phe-NH2

Analistas revisando el cromatograma de HPLC del lote actual — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Técnico supervisando un reactor de acero inoxidable durante el escalado — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Descripción general

SS-31 (elamipretide) is a tetrapeptide that selectively binds cardiolipin on the inner mitochondrial membrane, a key tool molecule in mitochondrial biology research.

Farmacología y mecanismo

Binding cardiolipin stabilizes the electron transport chain complexes, reducing electron leak and reactive oxygen species, restoring ATP synthesis efficiency.