Pinealon

Short-chain neuroactive tripeptide

Ficha técnicaLZH-012

Código: EDR
Semivida: Minutes plasma; BBB-permeable
Vía de investigación: Intranasal / SC (research)
Dianas moleculares: Neuronal gene-expression modulation · antioxidant response
Descubrimiento / divulgación: Khavinson family, St. Petersburg
Pureza objetivo: ≥ 98%
Almacenamiento recomendado: −20 °C, protegido de la luz. De 2 a 8 °C tras la reconstitución.

Sinónimos

EDR tripeptide

Aspecto

White lyophilized powder

Solubilidad

Freely water soluble

Secuencia

Glu-Asp-Arg

Analistas revisando el cromatograma de HPLC del lote actual — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Técnico supervisando un reactor de acero inoxidable durante el escalado — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Descripción general

Pinealon is the tripeptide Glu-Asp-Arg (EDR), part of the Khavinson family of short bioregulatory peptides.

Farmacología y mecanismo

Capable of crossing the blood-brain barrier, it influences neuronal gene expression, antioxidant pathways and cell responses associated with hypoxic injury.