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α-MSH fragment · Immunomodulatory peptide

KPV

C-terminal tripeptide of alpha-MSH

Ficha técnicaLZH-009
Código
α-MSH fragment
Fórmula
C19H28N6O4
Masa molecular
404.5 Da
Semivida
Short plasma half-life; mucosal residence reported
Vía de investigación
Oral / topical / SC (research)
Dianas moleculares
NF-κB downregulation · MC1R-independent anti-inflammatory pathway
Descubrimiento / divulgación
Identified as C-terminal active fragment of α-MSH, 1980s
Pureza objetivo
≥ 98%
Almacenamiento recomendado
−20 °C, protegido de la luz. De 2 a 8 °C tras la reconstitución.
Sinónimos
α-MSH(11-13), Lysine-Proline-Valine tripeptide
Aspecto
White lyophilized powder
Solubilidad
Freely water soluble
Secuencia
Lys-Pro-Val
Analistas revisando el cromatograma de HPLC del lote actual
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Técnico supervisando un reactor de acero inoxidable durante el escalado
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Descripción general

KPV is the C-terminal tripeptide fragment (Lys-Pro-Val) of alpha melanocyte stimulating hormone, retaining its key anti-inflammatory activity.

02

Farmacología y mecanismo

Downregulates NF-kB signaling and suppresses pro-inflammatory cytokine expression, with barrier-protective effects in gut and mucosal models.

03

Áreas de investigación

R.01
C-terminal tripeptide of alpha-MSH

Tool molecule for inflammatory bowel disease, skin inflammation and mucosal barrier studies.

04

Notas estructurales

Tripeptide Lys-Pro-Val. Small molecular weight allows multiple delivery routes.

Secuencia
Lys-Pro-Val
Uso exclusivo en investigación. No constituye asesoramiento médico ni se destina al diagnóstico o tratamiento.