GHK-Cu

Naturally occurring copper-binding tripeptide

Ficha técnicaLZH-008

Código: Copper tripeptide
Fórmula: C14H24N6O4·Cu
Masa molecular: 402.9 Da
Semivida: Plasma minutes; bound copper retained tissue-locally
Vía de investigación: Topical / SC (research)
Dianas moleculares: Copper-dependent enzymes (LOX, SOD1) · decorin / matrix gene network
Descubrimiento / divulgación: Identified by Pickart, 1973 (human plasma)
Pureza objetivo: ≥ 98%
Almacenamiento recomendado: −20 °C, protegido de la luz. De 2 a 8 °C tras la reconstitución.

Sinónimos

Copper tripeptide-1, Cu-GHK, Prezatide copper acetate

Aspecto

Deep blue lyophilized powder (Cu(II) chromophore)

Solubilidad

Freely soluble in water (deep blue solution)

Secuencia

Gly-His-Lys · Cu(II)

Analistas revisando el cromatograma de HPLC del lote actual — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Técnico supervisando un reactor de acero inoxidable durante el escalado — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Descripción general

GHK-Cu is the complex of the naturally occurring glycyl-histidyl-lysine tripeptide with copper, a classical tool in skin and connective tissue biology research.

Farmacología y mecanismo

Modulates copper-dependent enzyme activity, influences extracellular matrix remodeling, collagen and elastin synthesis, with antioxidant and gene expression effects.