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AEDG · Telomere research peptide

Epitalon

Pineal-derived tetrapeptide

Ficha técnicaLZH-011
Código
AEDG
Fórmula
C14H22N4O9
Masa molecular
390.4 Da
Semivida
Short plasma (~minutes); biological effects persist through gene regulation
Vía de investigación
Subcutaneous / intranasal (research)
Dianas moleculares
hTERT promoter modulation (in vitro) · pineal neuroendocrine axis
Descubrimiento / divulgación
Khavinson lab, St. Petersburg, 1980s-1990s
Pureza objetivo
≥ 98%
Almacenamiento recomendado
−20 °C, protegido de la luz. De 2 a 8 °C tras la reconstitución.
Sinónimos
Epithalon, AEDG tetrapeptide
Aspecto
White lyophilized powder
Solubilidad
Freely water soluble
Secuencia
Ala-Glu-Asp-Gly
Analistas revisando el cromatograma de HPLC del lote actual
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Técnico supervisando un reactor de acero inoxidable durante el escalado
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Descripción general

Epitalon is the tetrapeptide Ala-Glu-Asp-Gly, derived from the active structure of the pineal extract epithalamin.

02

Farmacología y mecanismo

Shown in vitro and in animal models to influence telomerase activity, melatonin secretion rhythm and neuroendocrine regulation.

03

Áreas de investigación

R.01
Pineal-derived tetrapeptide

A classical tool molecule for cellular replicative aging, circadian biology and aging of neuroendocrine axes.

04

Notas estructurales

Tetrapeptide Ala-Glu-Asp-Gly. Simple structure with good water solubility.

Secuencia
Ala-Glu-Asp-Gly
Uso exclusivo en investigación. No constituye asesoramiento médico ni se destina al diagnóstico o tratamiento.
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