← Back to libraryEntry · LZH-005

lyophilized

GHRH analog · GHRH analog

Tesamorelin

Stabilized growth hormone releasing hormone analog

Technical datasheetLZH-005

Code: GHRH analog
Half-life: ~26-38 min (SC)
Research route: Subcutaneous (research)
Molecular targets: GHRH receptor (pituitary)
Discovery / disclosure: Theratechnologies, approved 2010
Target purity: ≥ 98%
Recommended storage: −20°C, light protected. 2 to 8°C after reconstitution.

Aliases

TH9507, Egrifta

Appearance

White lyophilized powder

Solubility

Soluble in aqueous buffer, dilute acetic acid

Sequence

[trans-3-hexenoyl]-YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL

Analysts reviewing the HPLC chromatogram for the current batch — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technician monitoring a stainless steel reactor during scale-up — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Overview

Tesamorelin is a 44 amino acid stabilized GHRH analog, with an N-terminal trans-3-hexenoyl group that improves plasma stability.

Pharmacology and mechanism

Selectively acts on pituitary GHRH receptors, driving pulsatile growth hormone secretion and restoring physiological GH and IGF-1 axis rhythms.

Research areas

R.01

Stabilized growth hormone releasing hormone analog

Studied in visceral adipose deposition, HIV-associated lipodystrophy and cognitive or aging-related GH axis changes.

Structural notes

44 amino acid sequence with an N-terminal 3-hexenoyl modification, sharing high homology with native hGHRH.

Sequence

[trans-3-hexenoyl]-YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL

For research use only. Not medical advice. Not for diagnosis or treatment.

Related molecules

Dual receptor agonist

Open →

GIP / GLP-1 / GCG

Retatrutide

Triple receptor agonist

Open →

Elamipretide639.8 Da

SS-31

Mitochondrial targeting

Open →

GHRH + GHRP

CJC-1295 + Ipamorelin

Regenerative research

Open →