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lyophilized

ACTH(4-7) analog · Neurocognitive research

Semax

Stabilized ACTH(4-7) analog

Technical datasheetLZH-015

Code: ACTH(4-7) analog
Half-life: Short plasma; central activity hours
Research route: Intranasal (research)
Molecular targets: BDNF / NGF upregulation · monoamine modulation
Discovery / disclosure: Institute of Molecular Genetics, Moscow, 1980s
Target purity: ≥ 98%
Recommended storage: −20°C, light protected. 2 to 8°C after reconstitution.

Aliases

ACTH(4-7) PGP analog

Appearance

White lyophilized powder

Solubility

Water soluble

Sequence

Met-Glu-His-Phe-Pro-Gly-Pro

Analysts reviewing the HPLC chromatogram for the current batch — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technician monitoring a stainless steel reactor during scale-up — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Overview

Semax is a synthetic heptapeptide derived from the ACTH(4-7) sequence with a C-terminal Pro-Gly-Pro extension improving stability.

Pharmacology and mechanism

Upregulates BDNF and neurotrophin expression, modulates central monoamines and influences neural plasticity.

Research areas

R.01

Stabilized ACTH(4-7) analog

Classical tool peptide in ischemic brain injury, attention and learning memory studies.

Structural notes

Heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro.

Sequence

Met-Glu-His-Phe-Pro-Gly-Pro

For research use only. Not medical advice. Not for diagnosis or treatment.

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