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TP-7 analog · Anxiolytic and cognitive research

Selank

Stabilized analog of tuftsin

Technical datasheetLZH-014
Code
TP-7 analog
Half-life
Short plasma (~minutes); central effects persist hours
Research route
Intranasal (research)
Molecular targets
GABAergic, monoaminergic and BDNF expression modulation
Discovery / disclosure
Russian Academy of Sciences / Institute of Molecular Genetics, 1990s
Target purity
≥ 98%
Recommended storage
−20°C, light protected. 2 to 8°C after reconstitution.
Aliases
TP-7 stabilized analog
Appearance
White lyophilized powder
Solubility
Water soluble
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Analysts reviewing the HPLC chromatogram for the current batch
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technician monitoring a stainless steel reactor during scale-up
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Overview

Selank is a synthetic analog of the natural tuftsin peptide, a heptapeptide with a C-terminal stabilizing modification.

02

Pharmacology and mechanism

Modulates GABAergic, monoaminergic and neurotrophic factor expression, affecting brain regions linked to stress and cognition.

03

Research areas

R.01
Stabilized analog of tuftsin

Tool peptide in anxiety models, cognitive performance and immune-neuro modulation research.

04

Structural notes

Heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro with C-terminal Pro extension.

Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
For research use only. Not medical advice. Not for diagnosis or treatment.
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