Pinealon

Short-chain neuroactive tripeptide

Technical datasheetLZH-012

Code: EDR
Half-life: Minutes plasma; BBB-permeable
Research route: Intranasal / SC (research)
Molecular targets: Neuronal gene-expression modulation · antioxidant response
Discovery / disclosure: Khavinson family, St. Petersburg
Target purity: ≥ 98%
Recommended storage: −20°C, light protected. 2 to 8°C after reconstitution.

Aliases

EDR tripeptide

Appearance

White lyophilized powder

Solubility

Freely water soluble

Sequence

Glu-Asp-Arg

Analysts reviewing the HPLC chromatogram for the current batch — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technician monitoring a stainless steel reactor during scale-up — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Overview

Pinealon is the tripeptide Glu-Asp-Arg (EDR), part of the Khavinson family of short bioregulatory peptides.

Pharmacology and mechanism

Capable of crossing the blood-brain barrier, it influences neuronal gene expression, antioxidant pathways and cell responses associated with hypoxic injury.