Xiangyang Lizhi

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lyophilized

α-MSH fragment · Immunomodulatory peptide

KPV

C-terminal tripeptide of alpha-MSH

Technical datasheetLZH-009

Code: α-MSH fragment
Formula: C19H28N6O4
Molecular weight: 404.5 Da
Half-life: Short plasma half-life; mucosal residence reported
Research route: Oral / topical / SC (research)
Molecular targets: NF-κB downregulation · MC1R-independent anti-inflammatory pathway
Discovery / disclosure: Identified as C-terminal active fragment of α-MSH, 1980s
Target purity: ≥ 98%
Recommended storage: −20°C, light protected. 2 to 8°C after reconstitution.

Aliases

α-MSH(11-13), Lysine-Proline-Valine tripeptide

Appearance

White lyophilized powder

Solubility

Freely water soluble

Sequence

Lys-Pro-Val

Analysts reviewing the HPLC chromatogram for the current batch — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technician monitoring a stainless steel reactor during scale-up — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Overview

KPV is the C-terminal tripeptide fragment (Lys-Pro-Val) of alpha melanocyte stimulating hormone, retaining its key anti-inflammatory activity.

02

Pharmacology and mechanism

Downregulates NF-kB signaling and suppresses pro-inflammatory cytokine expression, with barrier-protective effects in gut and mucosal models.

03

Research areas

R.01

C-terminal tripeptide of alpha-MSH

Tool molecule for inflammatory bowel disease, skin inflammation and mucosal barrier studies.

04

Structural notes

Tripeptide Lys-Pro-Val. Small molecular weight allows multiple delivery routes.

Sequence

Lys-Pro-Val

For research use only. Not medical advice. Not for diagnosis or treatment.

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