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AEDG · Telomere research peptide

Epitalon

Pineal-derived tetrapeptide

Technical datasheetLZH-011
Code
AEDG
Formula
C14H22N4O9
Molecular weight
390.4 Da
Half-life
Short plasma (~minutes); biological effects persist through gene regulation
Research route
Subcutaneous / intranasal (research)
Molecular targets
hTERT promoter modulation (in vitro) · pineal neuroendocrine axis
Discovery / disclosure
Khavinson lab, St. Petersburg, 1980s-1990s
Target purity
≥ 98%
Recommended storage
−20°C, light protected. 2 to 8°C after reconstitution.
Aliases
Epithalon, AEDG tetrapeptide
Appearance
White lyophilized powder
Solubility
Freely water soluble
Sequence
Ala-Glu-Asp-Gly
Analysts reviewing the HPLC chromatogram for the current batch
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technician monitoring a stainless steel reactor during scale-up
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Overview

Epitalon is the tetrapeptide Ala-Glu-Asp-Gly, derived from the active structure of the pineal extract epithalamin.

02

Pharmacology and mechanism

Shown in vitro and in animal models to influence telomerase activity, melatonin secretion rhythm and neuroendocrine regulation.

03

Research areas

R.01
Pineal-derived tetrapeptide

A classical tool molecule for cellular replicative aging, circadian biology and aging of neuroendocrine axes.

04

Structural notes

Tetrapeptide Ala-Glu-Asp-Gly. Simple structure with good water solubility.

Sequence
Ala-Glu-Asp-Gly
For research use only. Not medical advice. Not for diagnosis or treatment.
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