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Delta sleep peptide · Sleep and neuroendocrine

DSIP

Delta sleep inducing peptide

Technical datasheetLZH-013
Code
Delta sleep peptide
Formula
C35H48N10O15
Molecular weight
848.8 Da
Half-life
~7-15 min (plasma)
Research route
Subcutaneous / IV (research)
Molecular targets
Neuroendocrine modulation; precise receptor not fully resolved
Discovery / disclosure
Schoenenberger & Monnier, Bern, 1977
Target purity
≥ 98%
Recommended storage
−20°C, light protected. 2 to 8°C after reconstitution.
Aliases
Delta sleep-inducing peptide
Appearance
White lyophilized powder
Solubility
Water soluble
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Analysts reviewing the HPLC chromatogram for the current batch
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technician monitoring a stainless steel reactor during scale-up
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Overview

DSIP is a nonapeptide originally isolated from rabbit brain perfusate, with activity in regulating slow-wave sleep.

02

Pharmacology and mechanism

Modulates neurotransmitter release and the circadian cortisol rhythm, with a buffering effect on the stress axis.

03

Research areas

R.01
Delta sleep inducing peptide

A classical tool peptide for sleep physiology, stress response and neuroendocrine rhythm studies.

04

Structural notes

Nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.

Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
For research use only. Not medical advice. Not for diagnosis or treatment.
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