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MOTS-c + 5-Amino-1MQ + NAD+ · Metabolic longevity complex

Biomtide

A mitochondrial peptide and NAD+ precursor research stack

Technical datasheetLZH-010
Code
MOTS-c + 5-Amino-1MQ + NAD+
Half-life
MOTS-c: ~hours; NAD+: rapid turnover; 5-Amino-1MQ: oral t½ ~hours
Research route
Subcutaneous (peptide); oral (small molecules) (research)
Molecular targets
AMPK axis (MOTS-c) · NNMT inhibition (5-Amino-1MQ) · sirtuins / PARPs (NAD+)
Discovery / disclosure
MOTS-c identified by Lee & Cohen, USC, 2015
Target purity
≥ 98%
Recommended storage
−20°C, light protected. 2 to 8°C after reconstitution.
Aliases
MOTS-c + 5-Amino-1MQ + NAD+
Appearance
White to slightly cream lyophilized powder
Solubility
MOTS-c and NAD+ water soluble; 5-Amino-1MQ DMSO/water
Sequence
MOTS-c: MRWQEMGYIFYPRKLR (16 aa, mtDNA 12S-rRNA derived)
Analysts reviewing the HPLC chromatogram for the current batch
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technician monitoring a stainless steel reactor during scale-up
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Overview

Biomtide is a research preparation combining the mitochondrial-derived peptide MOTS-c, the NNMT inhibitor 5-Amino-1MQ and NAD+, used to explore synergistic metabolic and aging interventions.

02

Pharmacology and mechanism

MOTS-c modulates AMPK and insulin sensitivity. 5-Amino-1MQ inhibits NNMT, preserving the SAM methyl pool.

NAD+ acts as a cofactor supporting sirtuin and mitochondrial function.

03

Research areas

R.01
A mitochondrial peptide and NAD+ precursor research stack

Used in combined models of metabolic syndrome, muscle function, mitochondrial biogenesis and aging intervention.

04

Structural notes

MOTS-c: 16 amino acid mitochondrial derived peptide. 5-Amino-1MQ: small molecule methyl quinoline. NAD+: native cofactor.

Sequence
MOTS-c: MRWQEMGYIFYPRKLR (16 aa, mtDNA 12S-rRNA derived)
For research use only. Not medical advice. Not for diagnosis or treatment.
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