TB-500 + BPC-157

A two-peptide toolkit for connective tissue and vascular repair research

Fiche techniqueLZH-007

Code: Regenerative duo
Demi-vie: TB-500: hours; BPC-157: short plasma, longer tissue residence
Voie de recherche: Subcutaneous / IM (research)
Cibles moléculaires: G-actin (TB-500) · VEGFR2 / NO-pathway / GH-R upregulation (BPC-157)
Découverte / divulgation: TB-500: synthetic Tβ4 active fragment, 1990s; BPC-157: Sikiric lab, Zagreb, 1991
Pureté cible: ≥ 98 %
Conservation recommandée: −20 °C, à l'abri de la lumière. De 2 à 8 °C après reconstitution.

Synonymes

Thymosin β4 fragment (1-4 + 17-23) + Body Protection Compound 157

Aspect

White lyophilized powder

Solubilité

Both highly water soluble

Séquence

TB-500: Ac-LKKTETQ | BPC-157: GEPPPGKPADDAGLV

Analystes examinant le chromatogramme HPLC du lot en cours — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technicien surveillant un réacteur en acier inoxydable pendant la montée en échelle — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Vue d'ensemble

TB-500 is an active fragment of thymosin beta 4. BPC-157 is a stable pentadecapeptide derived from a gastric protective protein.

Both are commonly used as a tool combination in tissue repair research.

Pharmacologie et mécanisme

TB-500 binds G-actin and supports cell migration and neovascularization. BPC-157 modulates VEGFR2, nitric oxide pathways and tendon fibroblast activity.