SS-31

Cardiolipin-binding mitochondrial peptide

Fiche techniqueLZH-004

Code: Elamipretide
Formule: C32H49N9O5
Masse moléculaire: 639.8 Da
Demi-vie: ~2 h (plasma); mitochondrial residence much longer
Voie de recherche: Subcutaneous / IV (research)
Cibles moléculaires: Cardiolipin (inner mitochondrial membrane)
Découverte / divulgation: Szeto-Schiller laboratory, Cornell, ca. 2004
Pureté cible: ≥ 98 %
Conservation recommandée: −20 °C, à l'abri de la lumière. De 2 à 8 °C après reconstitution.

Synonymes

Elamipretide, MTP-131, Bendavia

Aspect

White lyophilized powder

Solubilité

Freely soluble in water

Séquence

D-Arg-Dmt-Lys-Phe-NH2

Analystes examinant le chromatogramme HPLC du lot en cours — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technicien surveillant un réacteur en acier inoxydable pendant la montée en échelle — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Vue d'ensemble

SS-31 (elamipretide) is a tetrapeptide that selectively binds cardiolipin on the inner mitochondrial membrane, a key tool molecule in mitochondrial biology research.

Pharmacologie et mécanisme

Binding cardiolipin stabilizes the electron transport chain complexes, reducing electron leak and reactive oxygen species, restoring ATP synthesis efficiency.