CJC-1295 + Ipamorelin

GHRH analog plus selective GHRP combination

Fiche techniqueLZH-006

Code: GHRH + GHRP
Demi-vie: CJC-1295 DAC: ~6-8 d (albumin bound); Ipamorelin: ~2 h
Voie de recherche: Subcutaneous (research)
Cibles moléculaires: GHRH-R (CJC-1295) · GHSR-1a / ghrelin receptor (Ipamorelin)
Découverte / divulgation: ConjuChem (CJC-1295, 2005); Novo Nordisk (Ipamorelin, 1998)
Pureté cible: ≥ 98 %
Conservation recommandée: −20 °C, à l'abri de la lumière. De 2 à 8 °C après reconstitution.

Synonymes

CJC-1295 DAC + Ipamorelin

Aspect

White lyophilized powder

Solubilité

Both soluble in bacteriostatic water

Séquence

CJC-1295: YAibDAIFTQSYRKVLAQLSARKLLQDIMSR-Lys(MPA)-NH2 | Ipamorelin: Aib-His-D-2-Nal-D-Phe-Lys-NH2

Analystes examinant le chromatogramme HPLC du lot en cours — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technicien surveillant un réacteur en acier inoxydable pendant la montée en échelle — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Vue d'ensemble

CJC-1295 is a long-acting GHRH analog and Ipamorelin is a highly selective growth hormone releasing peptide. The pair is frequently studied together as a way to model physiological GH pulses.

Pharmacologie et mécanisme

CJC-1295 acts on the GHRH receptor, broadening GH secretion amplitude. Ipamorelin activates the ghrelin or GHSR-1a receptor, triggering pulse release with minimal effect on cortisol and prolactin.