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ACTH(4-7) analog · Neurocognitive research

Semax

Stabilized ACTH(4-7) analog

Fiche techniqueLZH-015
Code
ACTH(4-7) analog
Demi-vie
Short plasma; central activity hours
Voie de recherche
Intranasal (research)
Cibles moléculaires
BDNF / NGF upregulation · monoamine modulation
Découverte / divulgation
Institute of Molecular Genetics, Moscow, 1980s
Pureté cible
≥ 98 %
Conservation recommandée
−20 °C, à l'abri de la lumière. De 2 à 8 °C après reconstitution.
Synonymes
ACTH(4-7) PGP analog
Aspect
White lyophilized powder
Solubilité
Water soluble
Séquence
Met-Glu-His-Phe-Pro-Gly-Pro
Analystes examinant le chromatogramme HPLC du lot en cours
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technicien surveillant un réacteur en acier inoxydable pendant la montée en échelle
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Vue d'ensemble

Semax is a synthetic heptapeptide derived from the ACTH(4-7) sequence with a C-terminal Pro-Gly-Pro extension improving stability.

02

Pharmacologie et mécanisme

Upregulates BDNF and neurotrophin expression, modulates central monoamines and influences neural plasticity.

03

Domaines de recherche

R.01
Stabilized ACTH(4-7) analog

Classical tool peptide in ischemic brain injury, attention and learning memory studies.

04

Notes structurales

Heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro.

Séquence
Met-Glu-His-Phe-Pro-Gly-Pro
Réservé à un usage de recherche. Ne constitue pas un avis médical et n'est destiné ni au diagnostic ni au traitement.