Lizhi
TP-7 analog · Anxiolytic and cognitive research

Selank

Stabilized analog of tuftsin

Fiche techniqueLZH-014
Code
TP-7 analog
Demi-vie
Short plasma (~minutes); central effects persist hours
Voie de recherche
Intranasal (research)
Cibles moléculaires
GABAergic, monoaminergic and BDNF expression modulation
Découverte / divulgation
Russian Academy of Sciences / Institute of Molecular Genetics, 1990s
Pureté cible
≥ 98 %
Conservation recommandée
−20 °C, à l'abri de la lumière. De 2 à 8 °C après reconstitution.
Synonymes
TP-7 stabilized analog
Aspect
White lyophilized powder
Solubilité
Water soluble
Séquence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Analystes examinant le chromatogramme HPLC du lot en cours
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technicien surveillant un réacteur en acier inoxydable pendant la montée en échelle
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Vue d'ensemble

Selank is a synthetic analog of the natural tuftsin peptide, a heptapeptide with a C-terminal stabilizing modification.

02

Pharmacologie et mécanisme

Modulates GABAergic, monoaminergic and neurotrophic factor expression, affecting brain regions linked to stress and cognition.

03

Domaines de recherche

R.01
Stabilized analog of tuftsin

Tool peptide in anxiety models, cognitive performance and immune-neuro modulation research.

04

Notes structurales

Heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro with C-terminal Pro extension.

Séquence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Réservé à un usage de recherche. Ne constitue pas un avis médical et n'est destiné ni au diagnostic ni au traitement.