Pinealon

Short-chain neuroactive tripeptide

Fiche techniqueLZH-012

Code: EDR
Demi-vie: Minutes plasma; BBB-permeable
Voie de recherche: Intranasal / SC (research)
Cibles moléculaires: Neuronal gene-expression modulation · antioxidant response
Découverte / divulgation: Khavinson family, St. Petersburg
Pureté cible: ≥ 98 %
Conservation recommandée: −20 °C, à l'abri de la lumière. De 2 à 8 °C après reconstitution.

Synonymes

EDR tripeptide

Aspect

White lyophilized powder

Solubilité

Freely water soluble

Séquence

Glu-Asp-Arg

Analystes examinant le chromatogramme HPLC du lot en cours — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technicien surveillant un réacteur en acier inoxydable pendant la montée en échelle — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Vue d'ensemble

Pinealon is the tripeptide Glu-Asp-Arg (EDR), part of the Khavinson family of short bioregulatory peptides.

Pharmacologie et mécanisme

Capable of crossing the blood-brain barrier, it influences neuronal gene expression, antioxidant pathways and cell responses associated with hypoxic injury.