Xiangyang Lizhi

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lyophilized

α-MSH fragment · Immunomodulatory peptide

KPV

C-terminal tripeptide of alpha-MSH

Fiche techniqueLZH-009

Code: α-MSH fragment
Formule: C19H28N6O4
Masse moléculaire: 404.5 Da
Demi-vie: Short plasma half-life; mucosal residence reported
Voie de recherche: Oral / topical / SC (research)
Cibles moléculaires: NF-κB downregulation · MC1R-independent anti-inflammatory pathway
Découverte / divulgation: Identified as C-terminal active fragment of α-MSH, 1980s
Pureté cible: ≥ 98 %
Conservation recommandée: −20 °C, à l'abri de la lumière. De 2 à 8 °C après reconstitution.

Synonymes

α-MSH(11-13), Lysine-Proline-Valine tripeptide

Aspect

White lyophilized powder

Solubilité

Freely water soluble

Séquence

Lys-Pro-Val

Analystes examinant le chromatogramme HPLC du lot en cours — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technicien surveillant un réacteur en acier inoxydable pendant la montée en échelle — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Vue d'ensemble

KPV is the C-terminal tripeptide fragment (Lys-Pro-Val) of alpha melanocyte stimulating hormone, retaining its key anti-inflammatory activity.

02

Pharmacologie et mécanisme

Downregulates NF-kB signaling and suppresses pro-inflammatory cytokine expression, with barrier-protective effects in gut and mucosal models.

03

Domaines de recherche

R.01

C-terminal tripeptide of alpha-MSH

Tool molecule for inflammatory bowel disease, skin inflammation and mucosal barrier studies.

04

Notes structurales

Tripeptide Lys-Pro-Val. Small molecular weight allows multiple delivery routes.

Séquence

Lys-Pro-Val

Réservé à un usage de recherche. Ne constitue pas un avis médical et n'est destiné ni au diagnostic ni au traitement.

Molécules apparentées

Molécules apparentées

Catalogue complet →

GLP-1 RA4113.6 Da

Metabolic regulation

GIP / GLP-14813.5 Da

Dual receptor agonist

GIP / GLP-1 / GCG

Triple receptor agonist

Elamipretide639.8 Da

Mitochondrial targeting

CJC-1295 + Ipamorelin

GH pulse combination