GHK-Cu

Naturally occurring copper-binding tripeptide

Fiche techniqueLZH-008

Code: Copper tripeptide
Formule: C14H24N6O4·Cu
Masse moléculaire: 402.9 Da
Demi-vie: Plasma minutes; bound copper retained tissue-locally
Voie de recherche: Topical / SC (research)
Cibles moléculaires: Copper-dependent enzymes (LOX, SOD1) · decorin / matrix gene network
Découverte / divulgation: Identified by Pickart, 1973 (human plasma)
Pureté cible: ≥ 98 %
Conservation recommandée: −20 °C, à l'abri de la lumière. De 2 à 8 °C après reconstitution.

Synonymes

Copper tripeptide-1, Cu-GHK, Prezatide copper acetate

Aspect

Deep blue lyophilized powder (Cu(II) chromophore)

Solubilité

Freely soluble in water (deep blue solution)

Séquence

Gly-His-Lys · Cu(II)

Analystes examinant le chromatogramme HPLC du lot en cours — FIG. 201Analytical Lab
Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technicien surveillant un réacteur en acier inoxydable pendant la montée en échelle — FIG. 202Scale-up Operations
When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

Vue d'ensemble

GHK-Cu is the complex of the naturally occurring glycyl-histidyl-lysine tripeptide with copper, a classical tool in skin and connective tissue biology research.

Pharmacologie et mécanisme

Modulates copper-dependent enzyme activity, influences extracellular matrix remodeling, collagen and elastin synthesis, with antioxidant and gene expression effects.