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AEDG · Telomere research peptide

Epitalon

Pineal-derived tetrapeptide

Fiche techniqueLZH-011
Code
AEDG
Formule
C14H22N4O9
Masse moléculaire
390.4 Da
Demi-vie
Short plasma (~minutes); biological effects persist through gene regulation
Voie de recherche
Subcutaneous / intranasal (research)
Cibles moléculaires
hTERT promoter modulation (in vitro) · pineal neuroendocrine axis
Découverte / divulgation
Khavinson lab, St. Petersburg, 1980s-1990s
Pureté cible
≥ 98 %
Conservation recommandée
−20 °C, à l'abri de la lumière. De 2 à 8 °C après reconstitution.
Synonymes
Epithalon, AEDG tetrapeptide
Aspect
White lyophilized powder
Solubilité
Freely water soluble
Séquence
Ala-Glu-Asp-Gly
Analystes examinant le chromatogramme HPLC du lot en cours
FIG. 201Analytical Lab

Identity, purity and main-peak area are checked by reversed-phase HPLC against an in-house reference standard for this sequence. The chromatogram you see on the certificate of analysis is generated at this exact bench, by the analysts who release the batch.

Technicien surveillant un réacteur en acier inoxydable pendant la montée en échelle
FIG. 202Scale-up Operations

When a sequence moves from milligram research lots to multi-gram research supply, the same chemistry is transferred onto jacketed stainless reactors. Temperature, agitation and reagent equivalents are logged in real time so that the larger batch matches the analytical fingerprint of the small one.

01

Vue d'ensemble

Epitalon is the tetrapeptide Ala-Glu-Asp-Gly, derived from the active structure of the pineal extract epithalamin.

02

Pharmacologie et mécanisme

Shown in vitro and in animal models to influence telomerase activity, melatonin secretion rhythm and neuroendocrine regulation.

03

Domaines de recherche

R.01
Pineal-derived tetrapeptide

A classical tool molecule for cellular replicative aging, circadian biology and aging of neuroendocrine axes.

04

Notes structurales

Tetrapeptide Ala-Glu-Asp-Gly. Simple structure with good water solubility.

Séquence
Ala-Glu-Asp-Gly
Réservé à un usage de recherche. Ne constitue pas un avis médical et n'est destiné ni au diagnostic ni au traitement.
Molécules apparentées

Molécules apparentées

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