Molecules for neuroprotection, plasticity and cognitive function.
Neural research covers neuronal survival, synaptic plasticity, BDNF signalling and blood-brain barrier permeability. In models of ischaemia, traumatic brain injury and cognitive decline, peptides are used to read out functional recovery, synaptic density and neuroinflammation markers.
Cerebrolysin is a low molecular weight peptide mixture derived from porcine brain. In ischemic stroke models it improves neurological scores and reduces infarct volume. Research directions include the therapeutic window with reperfusion, dose density and long-term cognitive recovery.
Semax and Selank are synthetic intranasal peptides in the ACTH and tuftsin families. Semax is associated with upregulated BDNF expression. Selank has anxiolytic and immunomodulatory effects without sedation. Studies read out memory consolidation, attention task performance and HPA axis response.
Dihexa and P21 class molecules have been shown in animal models to increase dendritic spine density and to improve spatial memory in Alzheimer-like models. Research directions include combination with training, cognitive load and blood-brain barrier penetration efficiency.
Reference only for researchers in compliant settings.
Réservé à un usage de recherche. Ne constitue pas un avis médical et n'est destiné ni au diagnostic ni au traitement.
